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D) When mixed with other stimulants <br />1) increased stimulating effects on nervous system <br />2) synergetic effects when mixed with other stimulants <br />E) Tolerance and dependence <br />1) Tolerance can start occurring within four weeks with frequent use <br />2) Chronic high doses result in physical dependence and withdrawal sickness such as <br />sleep disturbances and apathy <br />3) Strong psychological dependence results even in low dose users <br />4) Severe medical problems can develop from impure batches of the drug. AIDS and <br />Hepatitis Type B virus can be contracted from sharing unsterile needles. <br />7.7.5 Work and family related problems <br />A) Very often away from work area <br />B) Agitation <br />C) Excessive absences <br />City of Eugene Page 7 -13 - DOTfFMCSA Drug & Alcohol Policy <br />September 2010 Information Packet <br />